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Evista. Women that may become pregnant should not take Raloxifene. It has a half life of 27.7 hours and is excreted through fecal matter. It is available by prescription only and is given through oral administration. Adverse reactions are mild, and they include hot flashes and leg cramps, and the possibility of serious blood clots that can occur in the legs, lungs, and eyes. Increased pain from leg swelling, trouble with respiratory function, pain in the chest, and changes in vision can occur when on the drug too.

Clomid. Clomid is given in 50 mg tablets, with a half life of 5 to 7 days, and most of the excretion is done through the urine, with a high bioavailability of over 90%. Some adverse side effects can occur like hot flashes, abdominal pain, blurred vision, reversible ovarian enlargement, and the formation of cysts. There can also be occurrences of uterine bleeding, nausea, and vomiting too. Some very rare effects which don’t happen that frequently include alopecia, and ovarian hyperstimulation syndrome. Sometimes, the drug is used in bodybuilding, but that is not its intended purpose. It blocks the effects of estrogen so it is used frequently by male anabolic steroid bodybuilders, and it sometimes used as a recovery drug as well taken at the end of a steroid cycle. It restores the body’s natural supply of testosterone.

Arimidex. Arimidex has a high bioavailability at 83% to 85%, 40% protein binding, 85% hepatic metabolism, 72 hour half life, and 11% rental excretion. It is administered orally and only given through prescription. The risk of recurrence of breast cancer was reduced by 40% with a slight risk of bone fracture in the patients that took the Arimidex. Since sex hormones can cause hyperplasia and differentiation of estrogen receptor sites, it is likely that the all the estrogen is reduced resulting in less chance of breast cancer coming back.

Femara. Breast cancer thrives on the presence of estrogen in the system. The bioavailability is 99.9% so that is almost unheard of and pleasantly above average for most medications. It has 60% protein binding mainly in Albumin with a half life of 2 days. Hypoestrogenism is a side effect that may result from taking this drug, but it is not likely. Some off-label use is prevalent, but statements by the FDA and other national health bodies persistently evaluate its use for these off-label activities as negative.